We developed a polygenic score training approach that allows direct inclusion of admixed individuals without the need for local ancestry inference and showed ancestry-diverse …
We develop an ontology-guided approach to ranking tissue-/cell-type-specific transcription factors (TFs) from chromatin accessibility data.
We performed a systematic assessment of the predictive performance of PRS models across >1,500 traits in UK Biobank and report 813 PRS models with significant predictive …
We analyzed the genetic basis of 35 blood and urine biomarkers in UK Biobank. We revealed that genetic effects on biomarkers inform the genetic basis of disease.
We present Global Biobank Engine as a platform to visualize genome- and phenome-wide associations and perform statistical inference using those association data.