https://tanigawalab.org/tags/precision-medicine/Precision MedicineHugo Blox Builder (https://hugoblox.com)enFri, 12 Jan 2024 00:00:00 +0000https://tanigawalab.org/media/logo_hu_6ec5cb994dd998e6.pnghttps://tanigawalab.org/tags/precision-medicine/https://tanigawalab.org/research/therapeutic-target-discovery/Fri, 12 Jan 2024 00:00:00 +0000https://tanigawalab.org/research/therapeutic-target-discovery/<p>Low success rates in clinical trials remain a major challenge in drug development. We leverage our expertise and bring human genetic evidence to therapeutic target discovery and validation. We envision nominating therapeutic targets for disease subtypes based on their underlying biology.</p> <ul> <li>Experiments by nature</li> <li>Rare variant associations</li> <li>Translational genomics and pharmacogenetics</li> </ul> <h2 id="representative-studies">Representative studies</h2> <div class="not-prose research-publication-cards"> <div class="container px-8 mx-auto xl:px-5 pt-0 pb-2 max-w-screen-xl"> <div class="grid gap-10 md:grid-cols-2 lg:grid-cols-3 lg:gap-10"> <div class="group bg-white/90 dark:bg-zinc-900/90 backdrop-blur-sm rounded-2xl ring-1 ring-zinc-900/5 dark:ring-white/10 shadow-lg overflow-hidden transition-all duration-300 ease-out hover:shadow-xl hover:shadow-blue-500/10 hover:-translate-y-2 focus-within:ring-2 focus-within:ring-blue-500/50" role="article" aria-labelledby="card-title-6b404868be28a9a46517c127c267c6a6"> <div class="relative overflow-hidden aspect-[16/9] bg-gradient-to-br from-zinc-100 to-zinc-200 dark:from-zinc-800 dark:to-zinc-900"> <a href="https://tanigawalab.org/publications/2020/angptl7/" class="block"> <img class="w-full h-full transition-transform duration-500 ease-out group-hover:scale-105 object-fill" srcset="https://tanigawalab.org/publications/2020/angptl7/featured_hu_36af76883d259e51.webp 400w, https://tanigawalab.org/publications/2020/angptl7/featured_hu_6f07eceb48a6a8cb.webp 600w, https://tanigawalab.org/publications/2020/angptl7/featured_hu_eaa7c1853a723df9.webp 800w, https://tanigawalab.org/publications/2020/angptl7/featured_hu_3be0d65e5744af49.webp 800w" sizes="(max-width: 768px) 100vw, (max-width: 1200px) 50vw, 33vw" src="https://tanigawalab.org/publications/2020/angptl7/featured_hu_36af76883d259e51.webp" width="800" height="450" loading="lazy" decoding="async" fetchpriority="high" style="position: absolute; height: 100%; width: 100%; inset: 0px; color: transparent;" alt="Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma featured image"> </a> <div class="absolute inset-0 pointer-events-none bg-gradient-to-t from-black/10 via-transparent to-transparent opacity-0 group-hover:opacity-100 transition-opacity duration-300"></div> </div> <div class="p-8 space-y-4"> <div class="flex flex-wrap gap-2"> <a href="https://tanigawalab.org/tags/rare-variants/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> Rare Variants </span> </a> <a href="https://tanigawalab.org/tags/uk-biobank/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> UK Biobank </span> </a> <a href="https://tanigawalab.org/tags/glaucoma/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> Glaucoma </span> </a> </div> <h3 id="card-title-6b404868be28a9a46517c127c267c6a6" class="text-xl font-bold tracking-tight text-zinc-900 dark:text-zinc-100 group-hover:text-blue-600 dark:group-hover:text-blue-400 transition-colors duration-200 leading-tight"> <a href="https://tanigawalab.org/publications/2020/angptl7/" class="hover:underline"> Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma </a> </h3> <p class="text-zinc-600 dark:text-zinc-400 text-base leading-relaxed line-clamp-3"> We identified an allelic series of rare protein-altering variants in ANGPTL7 that lower intraocular pressure and protect against glaucoma, highlighting ANGPTL7 as a therapeutic … </p> <div class="pt-3 border-t border-zinc-100 dark:border-zinc-800"> <div class="flex items-center gap-3 text-xs text-zinc-500 dark:text-zinc-500 flex-wrap mb-3"> <div class="flex items-center gap-2 min-w-0"> <div class="relative h-6 w-6 flex-shrink-0"> <img alt="avatar" class="rounded-full object-cover" src="https://tanigawalab.org/authors/yosuke-tanigawa/avatar_hu_e4b15cd8591d702.webp" width="24" height="24" loading="lazy" decoding="async" /> </div> <span class="truncate max-w-[9rem] text-sm">Yosuke Tanigawa, Ph.D.</span> </div> <span class="opacity-40">•</span> <time class="hidden sm:inline whitespace-nowrap" datetime="2020-09-01"> Sep 1, 2020 </time> <span class="hidden sm:inline opacity-40">•</span> <span class="hidden sm:inline whitespace-nowrap">1 min read</span> </div> <div class="pt-2 border-t border-zinc-200/50 dark:border-zinc-700/50"> <a href="https://tanigawalab.org/publications/2020/angptl7/" class="inline-flex items-center gap-2 text-primary-600 dark:text-primary-400 hover:text-primary-700 dark:hover:text-primary-300 font-medium text-sm transition-all duration-300 group/link"> <span>Read more</span> <svg class="w-4 h-4 transition-transform group-hover/link:translate-x-1" fill="none" stroke="currentColor" viewBox="0 0 24 24" aria-hidden="true"> <path stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="M17 8l4 4m0 0l-4 4m4-4H3"/> </svg> </a> </div> </div> </div> </div> <div class="group bg-white/90 dark:bg-zinc-900/90 backdrop-blur-sm rounded-2xl ring-1 ring-zinc-900/5 dark:ring-white/10 shadow-lg overflow-hidden transition-all duration-300 ease-out hover:shadow-xl hover:shadow-blue-500/10 hover:-translate-y-2 focus-within:ring-2 focus-within:ring-blue-500/50" role="article" aria-labelledby="card-title-ef9889d73ef787802367ab7da0066f65"> <div class="relative overflow-hidden aspect-[16/9] bg-gradient-to-br from-zinc-100 to-zinc-200 dark:from-zinc-800 dark:to-zinc-900"> <a href="https://tanigawalab.org/publications/2021/biomarkers/" class="block"> <img class="w-full h-full transition-transform duration-500 ease-out group-hover:scale-105 object-fill" srcset="https://tanigawalab.org/publications/2021/biomarkers/featured_hu_abc0309637612465.webp 400w, https://tanigawalab.org/publications/2021/biomarkers/featured_hu_7bdccae2a05a9d41.webp 600w, https://tanigawalab.org/publications/2021/biomarkers/featured_hu_7bab838c01042ff3.webp 800w, https://tanigawalab.org/publications/2021/biomarkers/featured_hu_4df762f8dcb3aa7d.webp 800w" sizes="(max-width: 768px) 100vw, (max-width: 1200px) 50vw, 33vw" src="https://tanigawalab.org/publications/2021/biomarkers/featured_hu_abc0309637612465.webp" width="800" height="450" loading="lazy" decoding="async" style="position: absolute; height: 100%; width: 100%; inset: 0px; color: transparent;" alt="Genetics of 35 blood and urine biomarkers in the UK Biobank featured image"> </a> <div class="absolute inset-0 pointer-events-none bg-gradient-to-t from-black/10 via-transparent to-transparent opacity-0 group-hover:opacity-100 transition-opacity duration-300"></div> </div> <div class="p-8 space-y-4"> <div class="flex flex-wrap gap-2"> <a href="https://tanigawalab.org/tags/resources/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> Resources </span> </a> <a href="https://tanigawalab.org/tags/uk-biobank/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> UK Biobank </span> </a> <a href="https://tanigawalab.org/tags/phenotyping/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> Phenotyping </span> </a> </div> <h3 id="card-title-ef9889d73ef787802367ab7da0066f65" class="text-xl font-bold tracking-tight text-zinc-900 dark:text-zinc-100 group-hover:text-blue-600 dark:group-hover:text-blue-400 transition-colors duration-200 leading-tight"> <a href="https://tanigawalab.org/publications/2021/biomarkers/" class="hover:underline"> Genetics of 35 blood and urine biomarkers in the UK Biobank </a> </h3> <p class="text-zinc-600 dark:text-zinc-400 text-base leading-relaxed line-clamp-3"> We analyzed the genetic basis of 35 blood and urine biomarkers in UK Biobank. We revealed that genetic effects on biomarkers inform the genetic basis of disease. </p> <div class="pt-3 border-t border-zinc-100 dark:border-zinc-800"> <div class="flex items-center gap-3 text-xs text-zinc-500 dark:text-zinc-500 flex-wrap mb-3"> <div class="flex items-center gap-2 min-w-0"> <div class="relative h-6 w-6 flex-shrink-0"> <img alt="avatar" class="rounded-full object-cover" src="https://tanigawalab.org/authors/yosuke-tanigawa/avatar_hu_e4b15cd8591d702.webp" width="24" height="24" loading="lazy" decoding="async" /> </div> <span class="truncate max-w-[9rem] text-sm">Yosuke Tanigawa, Ph.D.</span> </div> <span class="opacity-40">•</span> <time class="hidden sm:inline whitespace-nowrap" datetime="2021-04-07"> Apr 7, 2021 </time> <span class="hidden sm:inline opacity-40">•</span> <span class="hidden sm:inline whitespace-nowrap">1 min read</span> </div> <div class="pt-2 border-t border-zinc-200/50 dark:border-zinc-700/50"> <a href="https://tanigawalab.org/publications/2021/biomarkers/" class="inline-flex items-center gap-2 text-primary-600 dark:text-primary-400 hover:text-primary-700 dark:hover:text-primary-300 font-medium text-sm transition-all duration-300 group/link"> <span>Read more</span> <svg class="w-4 h-4 transition-transform group-hover/link:translate-x-1" fill="none" stroke="currentColor" viewBox="0 0 24 24" aria-hidden="true"> <path stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="M17 8l4 4m0 0l-4 4m4-4H3"/> </svg> </a> </div> </div> </div> </div> <div class="group bg-white/90 dark:bg-zinc-900/90 backdrop-blur-sm rounded-2xl ring-1 ring-zinc-900/5 dark:ring-white/10 shadow-lg overflow-hidden transition-all duration-300 ease-out hover:shadow-xl hover:shadow-blue-500/10 hover:-translate-y-2 focus-within:ring-2 focus-within:ring-blue-500/50" role="article" aria-labelledby="card-title-94519b69dfa52ecc0253c4896ddbbcfb"> <div class="relative overflow-hidden aspect-[16/9] bg-gradient-to-br from-zinc-100 to-zinc-200 dark:from-zinc-800 dark:to-zinc-900"> <a href="https://tanigawalab.org/publications/2024/hypometric-genetics/" class="block"> <img class="w-full h-full transition-transform duration-500 ease-out group-hover:scale-105 object-fill" srcset="https://tanigawalab.org/publications/2024/hypometric-genetics/featured_hu_b36fb2b39e5fedd0.webp 400w, https://tanigawalab.org/publications/2024/hypometric-genetics/featured_hu_2eb6072933534d96.webp 600w, https://tanigawalab.org/publications/2024/hypometric-genetics/featured_hu_2dabfaf00850e92d.webp 800w, https://tanigawalab.org/publications/2024/hypometric-genetics/featured_hu_c813a242e1a2edc7.webp 800w" sizes="(max-width: 768px) 100vw, (max-width: 1200px) 50vw, 33vw" src="https://tanigawalab.org/publications/2024/hypometric-genetics/featured_hu_b36fb2b39e5fedd0.webp" width="800" height="450" loading="lazy" decoding="async" style="position: absolute; height: 100%; width: 100%; inset: 0px; color: transparent;" alt="Hypometric genetics: Improved power in genetic discovery by incorporating quality control flags featured image"> </a> <div class="absolute inset-0 pointer-events-none bg-gradient-to-t from-black/10 via-transparent to-transparent opacity-0 group-hover:opacity-100 transition-opacity duration-300"></div> </div> <div class="p-8 space-y-4"> <div class="flex flex-wrap gap-2"> <a href="https://tanigawalab.org/tags/uk-biobank/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> UK Biobank </span> </a> <a href="https://tanigawalab.org/tags/phenotyping/"> <span class="inline-block px-2 py-1 bg-gray-100 dark:bg-gray-700 text-gray-700 dark:text-gray-300 text-xs rounded"> Phenotyping </span> </a> </div> <h3 id="card-title-94519b69dfa52ecc0253c4896ddbbcfb" class="text-xl font-bold tracking-tight text-zinc-900 dark:text-zinc-100 group-hover:text-blue-600 dark:group-hover:text-blue-400 transition-colors duration-200 leading-tight"> <a href="https://tanigawalab.org/publications/2024/hypometric-genetics/" class="hover:underline"> Hypometric genetics: Improved power in genetic discovery by incorporating quality control flags </a> </h3> <p class="text-zinc-600 dark:text-zinc-400 text-base leading-relaxed line-clamp-3"> We introduce &#34;hypometric genetics,&#34; an approach to investigate the genetic basis of binarized traits representing the presence of below-the-limit-of-quantification (BLQ) quality … </p> <div class="pt-3 border-t border-zinc-100 dark:border-zinc-800"> <div class="flex items-center gap-3 text-xs text-zinc-500 dark:text-zinc-500 flex-wrap mb-3"> <div class="flex items-center gap-2 min-w-0"> <div class="relative h-6 w-6 flex-shrink-0"> <img alt="avatar" class="rounded-full object-cover" src="https://tanigawalab.org/authors/yosuke-tanigawa/avatar_hu_e4b15cd8591d702.webp" width="24" height="24" loading="lazy" decoding="async" /> </div> <span class="truncate max-w-[9rem] text-sm">Yosuke Tanigawa, Ph.D.</span> </div> <span class="opacity-40">•</span> <time class="hidden sm:inline whitespace-nowrap" datetime="2024-10-22"> Oct 22, 2024 </time> <span class="hidden sm:inline opacity-40">•</span> <span class="hidden sm:inline whitespace-nowrap">1 min read</span> </div> <div class="pt-2 border-t border-zinc-200/50 dark:border-zinc-700/50"> <a href="https://tanigawalab.org/publications/2024/hypometric-genetics/" class="inline-flex items-center gap-2 text-primary-600 dark:text-primary-400 hover:text-primary-700 dark:hover:text-primary-300 font-medium text-sm transition-all duration-300 group/link"> <span>Read more</span> <svg class="w-4 h-4 transition-transform group-hover/link:translate-x-1" fill="none" stroke="currentColor" viewBox="0 0 24 24" aria-hidden="true"> <path stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="M17 8l4 4m0 0l-4 4m4-4H3"/> </svg> </a> </div> </div> </div> </div> </div> </div> </div>