In this study, led by Xiaohe (Lucy) Tian, we showed that ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores (PGS).
We developed GenoBoost, a polygenic score modeling approach, incorporating both additive and non-additive genetic dominance effects.
Robust and biologically interpretable genetic risk models for a broad range of individuals.
We developed a polygenic score training approach that allows direct inclusion of admixed individuals without the need for local ancestry inference and showed ancestry-diverse …
Polygenic risk score (PRS), an approach to estimate genetic liability to complex traits by aggregating the effects across multiple genetic variants, has attracted increasing …
We performed a systematic assessment of the predictive performance of PRS models across >1,500 traits in UK Biobank and report 813 PRS models with significant predictive …
[invited review written in Japanese] 日本語総説の執筆の機会をいただき、ゲノムワイド相関解析（GWAS）、ポリジェニック・リスク・スコア（polygenic risk score）、高次元データセットでの正則化つきの回帰モデル（penalized regression、Lasso 回帰など）に関する人類統計遺伝学の解析手法 …
Polygenic risk score (PRS) has been proposed for disease risk prediction with potential clinical relevance for some traits, but its personalized interpretation is generally …
In this study led by Emily Flynn, we discovered a surprising sex-specificity in the genetics of testosterone.