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Obesity

Integration of rare expression outlier-associated variants improves polygenic risk prediction featured image

Integration of rare expression outlier-associated variants improves polygenic risk prediction

Polygenic risk score (PRS), an approach to estimate genetic liability to complex traits by aggregating the effects across multiple genetic variants, has attracted increasing …

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology featured image

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

We developed DeGAs to decompose shared genetic associations across 2,138 UK Biobank phenotypes and identify their underlying pleiotropic structure.