Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder
Lei Hou and colleagues integrated peripheral immune epigenomics, whole-genome sequencing, and clinical data to study type I bipolar disorder.
Dissecting Alzheimer's disease heterogeneity by cross-trait polygenic prediction
Led by Bill Li, this work introduces cross-trait polygenic prediction as a strategy for using phenome-wide PGS libraries in deeply phenotyped cohorts to reveal multiple polygenic …
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, yet its epigenetic underpinnings remain elusive.
Disease heterogeneity dissection
Statistical and computational methods for understanding interindividual differences in disease.
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Human microglial state dynamics in Alzheimer's disease progression
Here we report 194,000 single-nucleus microglial transcriptomes and epigenomes across 443 human subjects and diverse Alzheimer's disease pathological phenotypes.
Polygenic risk modeling with latent trait-related genetic components
Polygenic risk score (PRS) has been proposed for disease risk prediction with potential clinical relevance for some traits, but its personalized interpretation is generally …