Alzheimers

Alzheimers Epigenomics Disease Heterogeneity

Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, yet its epigenetic underpinnings remain elusive.

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Human microglial state dynamics in Alzheimer's disease progression featured image
Alzheimers Epigenomics Disease Heterogeneity

Human microglial state dynamics in Alzheimer's disease progression

Here we report 194,000 single-nucleus microglial transcriptomes and epigenomes across 443 human subjects and diverse Alzheimer's disease pathological phenotypes.

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