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Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide featured image

Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide

Using two independent datasets from genotyped cohorts (UK Biobank and electronic medical record (EMR) in Vanderbilt University Medical Center), we quantified the heritability …

Global Biobank Engine screenshot

Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics

We present Global Biobank Engine as a platform to visualize genome- and phenome-wide associations and perform statistical inference using those association data.

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study featured image

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

Using the UK Biobank population cohort, we investigated the genetic effects of Protein-truncating variants (PTVs) and the clinical impacts.