Polygenic risk score (PRS) has been proposed for disease risk prediction with potential clinical relevance for some traits, but its personalized interpretation is generally …
In this project led by Junyang Qian, we developed BASIL, a novel algorithm to fit large-scale L1 penalized (Lasso) regression model using an iterative procedure, and implemented R …
We propose extending the BASIL/snpnet algorithm to fit the L1 penalized Cox proportional hazards model using a large-scale dataset from a genotyped cohort.
In this study led by Emily Flynn, we discovered a surprising sex-specificity in the genetics of testosterone.
We identified an allelic series of rare protein-altering variants in ANGPTL7 that lower intraocular pressure and protect against glaucoma, highlighting ANGPTL7 as a therapeutic …
Large-scale population-based genotyped biobanks with dense phenotypic information provide opportunities for genetic analysis at scale.
We developed DeGAs to decompose shared genetic associations across 2,138 UK Biobank phenotypes and identify their underlying pleiotropic structure.
Using two independent datasets from genotyped cohorts (UK Biobank and electronic medical record (EMR) in Vanderbilt University Medical Center), we quantified the heritability …
We present Global Biobank Engine as a platform to visualize genome- and phenome-wide associations and perform statistical inference using those association data.