Large-scale multivariate sparse regression with applications to UK Biobank
In this study led by Junyang Qian, we present a method to fit sparse multi-variate and multi-response regression model.
Integration of rare expression outlier-associated variants improves polygenic risk prediction
Polygenic risk score (PRS), an approach to estimate genetic liability to complex traits by aggregating the effects across multiple genetic variants, has attracted increasing …
Significant Sparse Polygenic Risk Scores across 813 traits in UK Biobank
We performed a systematic assessment of the predictive performance of PRS models across >1,500 traits in UK Biobank and report 813 PRS models with significant predictive …
Bayesian model comparison for rare-variant association studies of multiple phenotypes
When applied to cardiometabolic biomarker traits in UK Biobank, MRP identified gene-biomarker associations that were not identified in single-variant GWAS analysis.
A cross-population atlas of genetic associations for 220 human phenotypes
Using a set of GWAS summary statistics of diseases characterized from both European (UK Biobank and FinnGen) and East Asian (Biobank Japan) populations, we dissected latent DeGAs …
APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups
We examined the causal relationship between the genetically increased triglycerides and the risk of coronary artery diseases in Asian Indians.
Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility
This study evaluated symptom-based COVID-19 case prediction across cohorts and used the predicted phenotype in a GWAS of COVID-19 susceptibility.
Mapping the human genetic architecture of COVID-19
This consortia flagship manuscript has 2000+ authors.
Fast Numerical Optimization for Genome Sequencing Data in Population Biobanks
In this paper led by Ruilin Li, we describe memory-efficient implementation of snpnet (sparse-snpnet and snpnet-v2).
[Review in Japanese] 複数の表現型を用いた人類遺伝統計学の大規模情報解析 (Large-scale human genetic statistical inference with multiple phenotypes)
[invited review written in Japanese] 日本語総説の執筆の機会をいただき、ゲノムワイド相関解析（GWAS）、ポリジェニック・リスク・スコア（polygenic risk score）、高次元データセットでの正則化つきの回帰モデル（penalized regression、Lasso 回帰など）に関する人類統計遺伝学の解析手法 …