Polygenic risk score (PRS), an approach to estimate genetic liability to complex traits by aggregating the effects across multiple genetic variants, has attracted increasing …
We performed a systematic assessment of the predictive performance of PRS models across >1,500 traits in UK Biobank and report 813 PRS models with significant predictive …
When applied to cardiometabolic biomarker traits in UK Biobank, MRP identified gene-biomarker associations that were not identified in single-variant GWAS analysis.
Using a set of GWAS summary statistics of diseases characterized from both European (UK Biobank and FinnGen) and East Asian (Biobank Japan) populations, we dissected latent DeGAs …
We examined the causal relationship between the genetically increased triglycerides and the risk of coronary artery diseases in Asian Indians.
This consortia flagship manuscript has 2000+ authors.
In this paper led by Ruilin Li, we describe memory-efficient implementation of snpnet (sparse-snpnet and snpnet-v2).
[invited review written in Japanese] 日本語総説の執筆の機会をいただき、ゲノムワイド相関解析（GWAS）、ポリジェニック・リスク・スコア（polygenic risk score）、高次元データセットでの正則化つきの回帰モデル（penalized regression、Lasso 回帰など）に関する人類統計遺伝学の解析手法 …
We analyzed the genetic basis of 35 blood and urine biomarkers in UK Biobank. We revealed that genetic effects on biomarkers inform the genetic basis of disease.
In this paper led by Ruilin Li, we describe a new method to fit a sparse Cox Model for multiple time-to-event phenotypes from a large-scale (> 1 million features) genetic dataset.