Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder
Lei Hou and colleagues integrated peripheral immune epigenomics, whole-genome sequencing, and clinical data to study type I bipolar disorder.
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, yet its epigenetic underpinnings remain elusive.
Hypometric genetics: Improved power in genetic discovery by incorporating quality control flags
We introduce "hypometric genetics," an approach to investigate the genetic basis of binarized traits representing the presence of below-the-limit-of-quantification (BLQ) quality …
A polygenic score method boosted by non-additive models
We developed GenoBoost, a polygenic score modeling approach, incorporating both additive and non-additive genetic dominance effects.
Power of inclusion: Enhancing polygenic prediction with admixed individuals
We developed a polygenic score training approach that allows direct inclusion of admixed individuals without the need for local ancestry inference and showed ancestry-diverse …
Human microglial state dynamics in Alzheimer's disease progression
Here we report 194,000 single-nucleus microglial transcriptomes and epigenomes across 443 human subjects and diverse Alzheimer's disease pathological phenotypes.
A second update on mapping the human genetic architecture of COVID-19
The consortia released a manuscript describing the results from meta-analysis data freeze version 7.
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells
- Single-cell dissection of obesity-exercise axis in adipose-muscle tissues - Data Browser
WhichTF is dominant in your open chromatin data?
We develop an ontology-guided approach to ranking tissue-/cell-type-specific transcription factors (TFs) from chromatin accessibility data.
