Congratulations to Tanya Wang on completing her MS in Biostatistics
Tanya Wang graduated from UCLA with an MS in Biostatistics and will continue her next chapter at Yale.
Yosuke Tanigawa, Ph.D.
Assistant Professor
Mapping the biological basis of heterogeneity in disease.
Disease heterogeneity dissection
Biomedical data science
Statistical genetics
Computational genomics
Polygenic prediction
Therapeutic target discovery
Yosuke Tanigawa is an Assistant Professor in the Department of Bioengineering at UCLA. He leads the Tanigawa Lab, which studies why individuals with the same diagnosis differ in disease onset, progression, and treatment response.
The lab develops statistical and computational methods for large-scale genetic, genomic, and phenotypic data. The work spans disease heterogeneity dissection, ancestry-aware polygenic prediction, and therapeutic target discovery from human genetics.
Before joining UCLA in July 2025, Yosuke trained at the MIT Computational Biology Lab with Manolis Kellis. He received his PhD in Biomedical Informatics at Stanford University, where he worked with Manuel Rivas and Gill Bejerano.
The lab values scientific rigor, open science, and clear communication. We aim to make complex human genetics accessible without losing scientific precision.
Posts and Publications
Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder
Lei Hou and colleagues integrated peripheral immune epigenomics, whole-genome sequencing, and clinical data to study type I bipolar disorder.
Dissecting Alzheimer's disease heterogeneity by cross-trait polygenic prediction
Led by Bill Li, this work introduces cross-trait polygenic prediction as a strategy for using phenome-wide PGS libraries in deeply phenotyped cohorts to reveal multiple polygenic …
UCLA Tanigawa Lab is recruiting (2026)
The Tanigawa Lab at UCLA is recruiting students and postdoctoral researchers in statistical genetics, computational genomics, and precision medicine.
Mentoring philosophy in the Tanigawa Lab
How I think about mentorship, scientific training, expectations, and professional growth across career stages.
sc4D: spatio-temporal single-cell transcriptomics analysis through embedded optimal transport identifies joint glial response to Alzheimer's disease pathology
Led by Ishir Rao, this work introduces sc4D, a spatio-temporal single-cell transcriptomics framework for modeling disease progression with embedded optimal transport.
PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores
In this study, led by Xiaohe (Lucy) Tian, we showed that ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores (PGS).
Yosuke received Early Career Award from Japan Science and Technology Agency
Yosuke received a JST PRESTO award to support research on mathematical modeling of interindividual differences in disease.
UCLA Tanigawa Lab is recruiting
The Tanigawa Lab at UCLA is recruiting students and postdoctoral researchers in statistical genetics, computational genomics, and precision medicine.
Joining UCLA as Assistant Professor in Bioengineering
Yosuke Tanigawa joined UCLA Bioengineering in July 2025 to launch a research program on disease heterogeneity.