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William Li

William Li

Former Undergraduate Mentee

Undergraduate mentee (UROP) at MIT who applied polygenic score prediction to investigate Alzheimer's disease heterogeneity. Now MD-PhD student at Harvard.

Polygenic score prediction Alzheimer's disease Disease heterogeneity

Bill was an undergraduate mentee (UROP) at MIT who applied polygenic score prediction to investigate Alzheimer’s disease heterogeneity. Now MD-PhD student at Harvard.

Posts and Publications

Dissecting Alzheimer's disease heterogeneity by cross-trait polygenic prediction

Led by Bill Li, this work introduces cross-trait polygenic prediction as a strategy for using phenome-wide PGS libraries in deeply phenotyped cohorts to reveal multiple polygenic …

PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores featured image

PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores

In this study, led by Xiaohe (Lucy) Tian, we showed that ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores (PGS).